Historically, OME has not been funded directly, since the software and file formats themselves are not hypothesis-driven research. Rather, OME has been developed to facilitate specific research with an acute need for such tools.

LOCI's OME work is NSF- and NIH-funded through research grants. The Goldberg lab is funded directly through NIH. Development of OME in the Swedlow lab is supported by the Wellcome Trust and the BBSRC.