UW-Madison and Morgridge researchers associate collagen architecture with glioblastoma patient survival

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A new report in the Journal of Neurosurgery, "Association of collagen architecture with glioblastoma patient survival" by University of Wisconsin-Madison investigators Kelli PointerCellular and Molecular Biology Graduate Program in the laboratory of John Kuo, Department of Neurological Surgery and Kevin EliceiriLaboratory of Optical and Computational Instrumentation (LOCI) as well as Alex Schroeder, Medical Physics Graduate ProgramLOCI, and the Morgridge Institute for Research shows a correlation between collagen and glioblastoma progression.  The group was the first to visualize collagen architecture in glioblastoma using the Optical Workstation at LOCI: a multiphoton laser scanning system with second harmonic generation (SHG) imaging capabilities.  The group showed that glioblastoma can be visualized by SHG and collagen alignment can be correlated with tumor invasiveness and patient survival.                                                                                                                                                                                              

Glioblastoma histology slide CC-BY-SA-3.0