Eliceiri is an internationally known expert in advanced light microscopy in the Laboratory for Optical and Computational Instrumentation (LOCI) in the Graduate School and College of Engineering. The mission of LOCI is to develop advanced optical and computational techniques for imaging and experimentally manipulating living specimens.
As director of LOCI, Eliceiri oversees the day-to-day operations of the lab and has initiated research collaborations with faculty across the university. Several collaborations have resulted in high-impact publications and grant awards. He is also the principal investigator of a National Institutes of Health-funded project to develop software to annotate and archive microscopy data.